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My RPMs go crazy and I lose power (speed drops) and A/T over heat light goes on

My 2005 Honda Pilot has 228.000 miles on it. I’ve taken good care of it. Purchased at 170,000 miles. I do a fair amount of highway driving. The Pilot suddenly started losing power/speed. The RPMs were all over the gauge. Engine sounded like it was “racing”...no speed or power. A/T light went on. Stopped driving until it cooled off. Limped home. Mechanic put it on the computer per the findings,. I replaced the throttle body. After driving about 50 miles with new TB...the problem started again. HELP!
Linda