I've got a 2010 Odyssey Touring that's got some vibration in the front end once you get up over 60. It feels like it's mostly on the passenger side. The tires are wearing unevenly, too. Both tires had wire showing on the passenger side of the tire while the driver side of the tire had plenty of tread left. Obviously there's an alignment issue, but with the severity of that vibration I'm suspecting wheel bearings and possibly some kind of suspension issue. Any thoughts or ideas on how to tackle this short of just taking it in and letting a mechanic bend me over a barrel?

 

If you worn down the tires so much that the wires are showing then they are not balanced
Before doing wheel bearing, try replacing tires first. Wheel alignment and balancing necessary.
You can look over several Youtube videos if you feel like trying to DIY it??
But, tires are a must and no getting around it.

 

Agreed. Those have been replaced, and that shimmy is still there. That's got to be what caused the tires to wear funny in the first place. I'm guessing it's time to rip in and look at the bearings.

 

First jack up the front wheels and hands on 12 and 6 and try to move the wheel
Then hands at 9 and 3 and see if there is play.
May need to observe the outer tie rod end or ball joints.
Spin wheel and see if there is play or noise

Good luck

 

Until you get good balanced tires and wheels you will be spinning yours.